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KMID : 1161520180220050281
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Animal Cells and Systems
2018 Volume.22 No. 5 p.281 ~ p.288
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Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment
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Park Min-Hee
Baek Bo-Sung
Jin Hee-Kyung
Bae Jae-Sung
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Abstract
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Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy.
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KEYWORD
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Bone marrow damage, bone marrow microenvironment cells, Chemotherapy, hematopoietic stem cell, neuropeptide Y-derived recombinant peptides
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